Assessment of Analgesic Potential of Dibenzylidene Derivatives of Cyclopentanone

Background: In the search for novel analgesic agents as current pain management options, Dibenzylidene-acetophenone analogues have emerged as potential candidates, and this is due to their diverse pharmacological activities, laying the foundation for innovative exploration into the analgesic potentials of cyclopentanone derivatives.

Aim of the Study: This study is aimed at the determination of the analgesic potentials of cyclopentanone derivatives which include; 2,5-bis[(4-dimethylaminophenylmethylidene] cyclopentan-1-one, 2,5-bis [(4-methoxyphenyl) methylidene] cyclopentan-1-one, 2,5-diethylidenecyclopentan-1-one, 2,5 diphenylmethylidenepentan-1-one, and 2,5-dibenzodioxoylmethyledenecyclopentan-1-one (D6-D10 respectively).

Methodology: The study measured analgesia potential using the hot plate and tail flick model. The mice were divided into five groups, (GPs): GP I and V were control group (0.2 ml/kg of distilled water) and standard group (50 mg/kg Tramadol Hydrochloride) respectively, GP II to IV were administered the different doses (500, 1000, and 1500 mg/kg) of the test compounds respectively and evaluated 30 min afterwards. The latency to pain was observed at 30, 60 and 90 minutes in all GPs respectively.

Results: Promising analgesic potential was discovered in: D6 showed significant increase in analgesic potential (p<0.0487) at 60 mins with a dose of 1500 mg/kg; D7 showed significant increase (p<0.0099) at 60 min with 500mg/kg and D10 also showed significant increase (p<0.0232) at 30 min with 1000mg/kg for the hot plate study model. On the tail-flick model, D6 showing significant increase (p<0.0451) at 90min with 1500 mg/kg while in contrast D8 showed significant increase(p<0.0001) at 30 min with 1500 mg/kg and D10 showed significant increase (p<0.0001) at 30 min with 1000 mg/kg for the.

Conclusion: The study showed remarkable analgesic potential in D6, D7, and D10 cyclopentanone derivatives on the hot plate model while D6, D8 and D10 cyclopentanone derivatives showed remarkable analgesic potential on the tail-flick model.